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KMID : 0390020100200010030
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Pediatric Allergy and Respiratory Disease
2010 Volume.20 No. 1 p.30 ~ p.40
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Relationship between Allergic Rhinitis and Asthma in High School Students in Korea
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Song Young-Hwa
Kwon Ji-Won
Kim Byoung-Ju
Kim Bong-Seong
Kim Ja-Hyeong
Kim Hyo-Bin
Lee So-Yeon
Yu Jin-Ho
Yoo Sun-Mi
Hong Soo-Jong
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Abstract
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Purpose:The aim of this study was to determine whether allergic rhinitis (AR) without asthma is associated with bronchial hyperresponsiveness (BHR) and symptoms of asthma in Korean adolescents.
Methods:A questionnaire survey was conducted on 724 high school students (males 556; females, 168) from Seoul City. We also performed the lung function test, methacholine challenge test, skin prick test, and allergy-related blood biomarkers. This cross-sectional study was conducted in the subjects excluding current asthmatic patients.
Results:AR (+), BHR (+) patients tended to show a high prevalence of wheeze ever, a high diagnosis rate of asthma ever, low forced expiratory volume in one second (FEV1), low forced expiratory flow at the 25% and 75% of pulmonary volume (FEF25-75%) high total IgE and frequent sensitizaion to house dust mites compared with AR (+), BHR (-) patients. In atopy AR (+) group, wheeze ever and treatment of asthma during the last 12 months were significantly higher than atopy (-), AR (-) patients or atopy (+), AR (-) patients (P＜0.05). In atopy (+), AR (+) patients, BHR and peripheral eosinophil percent were significantly higher than in other patients (P＜0.05) and PC20 was also significantly lower than in other patients (P＜0.05).
Conclusion: BHR in current AR was associated with FEV1, FEF25-75%, total IgE, and sensitization to house dust mites. Current AR was associated with symptoms of asthma, peripheral eosinophilia and BHR, regardless of atopy. This study showed a significant association between allergic rhinitis and asthma or BHR among Korean adolescents. This cross-sectional study supports the concept of ’one airway, one disease’ between the AR and asthma.
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KEYWORD
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Brronchial hyperresponsiveness, Allergic rhinitis, Asthma, One airway disease
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